Calprotectin-Mediated Zinc Chelation Inhibits Pseudomonas aeruginosa Protease Activity in Cystic Fibrosis Sputum
Danielle M. Vermilyea, Alex W. Crocker, Alex H. Gifford, Deborah A. Hogan
Abstract
The factors that contribute to worse outcomes in individuals with cystic fibrosis (CF) with chronic Pseudomonas aeruginosa infections are not well understood. Therefore, there is a need to understand environmental factors within the CF airway that contribute to P. aeruginosa colonization and infection.
Topics & Concepts
Cystic fibrosisBiologySputumPseudomonas aeruginosaCalprotectinMicrobiologyProteaseChelationZincInternal medicineBiochemistryBacteriaTuberculosisEnzymePathologyMedicineChemistryOrganic chemistryDiseaseInflammatory bowel diseaseGeneticsTrace Elements in HealthBacterial biofilms and quorum sensingCystic Fibrosis Research Advances