Oxetane as a part of modern medicinal chemistry toolbox: the advanced synthesis of 3,3-disubstituted building blocks
Eduard Litskan, Oleksandr V. Semenchenko, Serhii Lynnyk, Dmitry Granat, Bohdan V. Vashchenko, Anastasiia Hoida, Daria A. Tolmachova, Dmitry A. Lega, Oleksandr O. Grygorenko, Dmytro M. Volochnyuk, Sergey V. Ryabukhin
Abstract
Despite numerous potential advantages of oxetanes, their restricted synthetic accessibility and propensity to ring-opening hamper their wide application in drug design. In this research, we have shown our solutions for this problem.
Topics & Concepts
OxetaneChemistryToolboxCombinatorial chemistryOrganic chemistryProgramming languageComputer scienceChemical Reactions and Isotopesbioluminescence and chemiluminescence research