The HPV Induced Cancer Resource (THInCR): a Suite of Tools for Investigating HPV-Dependent Human Carcinogenesis
Mikhail Salnikov, Steven F. Gameiro, Peter YF. Zeng, John W. Barrett, Anthony C. Nichols, Joe S. Mymryk
Abstract
The suite of analytical tools of THInCR provides the opportunity to investigate the roles that candidate target genes identified in cell lines or other model systems contribute to in actual HPV-dependent human cancers and is based on large-scale TCGA data sets. Expression of target genes, including both mRNA and microRNA, can be correlated with HPV gene expression, epigenetic changes in DNA methylation, patient survival, and numerous immune features, like leukocyte infiltration, interferon gamma response, T cell response, etc.
Topics & Concepts
CarcinogenesisHuman Protein AtlasBiologyEpigenomicsCancer researchCancerCervical cancermicroRNAGeneDNA methylationGene expressionGeneticsProtein expressionCervical Cancer and HPV ResearchHead and Neck Cancer StudiesCancer-related molecular mechanisms research