Dileucine ingestion is more effective than leucine in stimulating muscle protein turnover in young males: a double blind randomized controlled trial
Kevin J.M. Paulussen, Rafael A. Alamilla, Amadeo F. Salvador, Colleen F. McKenna, Andrew T. Askow, Hsin-Yu Fang, Zhong Li, Alexander Ulanov, Scott A. Paluska, John A. Rathmacher, Ralf Jäger, Martin Purpura, Nicholas A. Burd
Abstract
The role of dipeptides as anabolic agents remains unresolved in humans. We show that the ingestion of 2 g dileucine increased plasma dileucine concentrations and resulted in an enhancement of muscle protein turnover by stimulating an increase in muscle protein synthesis rates in healthy young males. The ingestion of 2 g leucine, however, did not stimulate an increase in muscle protein turnover. Our work provides the first insights into the effects of dipeptides on human protein metabolism.
Topics & Concepts
IngestionAnabolismLeucineProtein turnoverBiologyEndocrinologyProtein metabolismInternal medicineMetabolismProtein biosynthesisBiochemistryAmino acidMedicineMuscle metabolism and nutritionBiochemical effects in animalsDiet and metabolism studies