Immune microenvironment modulation for treating inflammatory periodontal bone defects using a dynamic dual-responsive hydrogel
Jiufan Yao, Chi Zhang, C. Yu, Liang Wu, Lingping Tan, Weichang Li, Li Gao, Chuanjiang Zhao
Abstract
experiments demonstrated that this hydrogel system maintains local periodontal immune homeostasis by inhibiting the expression of inflammatory factors, reducing oxidative stress, and regulating macrophage polarization, thereby providing a favorable environment for bone regeneration in the inflammatory periodontal environment and significantly enhancing the regenerative effect of periodontal bone defects. This dynamic cross-linked hydrogel system incorporating SA provides an effective strategy for the regenerative treatment of periodontal bone defects.
Topics & Concepts
Immune systemDual (grammatical number)Materials scienceImmune modulationModulation (music)InflammationImmunologyMedicineAestheticsPhilosophyArtLiterature3D Printing in Biomedical ResearchPeriodontal Regeneration and TreatmentsGraphene and Nanomaterials Applications