Palladium-catalyzed intramolecular asymmetric hydrocyclopropanylation of alkynes: synthesis of cyclopropane-fused γ-lactams
Han-Ze Lin, Zhuang Qi, Qi-Min Wu, Yong-Yu Jiang, Jin‐Bao Peng
Abstract
)-H activation has been developed for the synthesis of cyclopropane-fused γ-lactams. The presented strategy proceeds in a selective and 100% atom-economical manner. A range of cyclopropane-fused γ-lactams were prepared from readily available substrates in good yields and enantioselectivities with a chiral phosphoramidite ligand.
Topics & Concepts
CyclopropaneIntramolecular forcePhosphoramiditePalladiumChemistryCatalysisLigand (biochemistry)Combinatorial chemistryStereochemistryOrganic chemistryRing (chemistry)ReceptorDNABiochemistryOligonucleotideCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Alkyne Reactions