Projections of Drug-Drug Interactions Caused by Time-Dependent Inhibitors of Cytochrome P450 1A2, 2B6, 2C8, 2C9, 2C19, and 2D6 Using In Vitro Data in Static and Dynamic Models
Elaine Tseng, Jian Lin, Timothy J. Strelevitz, Ethan DaSilva, Theunis C. Goosen, R. Scott Obach
Topics & Concepts
In vitroDrugCytochrome P450PharmacologyChemistryMedicineEnzymeBiochemistryPharmacogenetics and Drug MetabolismComputational Drug Discovery MethodsAnalytical Chemistry and Chromatography