Supramolecular detoxification of nitrogen mustard<i>via</i>host–guest encapsulation by carboxylatopillar[5]arene
Siyuan Zhou, Yi Chen, Jie Xu, Yongfei Yin, Jianqing Yu, Wei Liu, Shigui Chen, Lu Wang
Abstract
experiments also indicated that the toxicity of the aziridinium salt (2) is inhibited with the formation of a stable host-guest complex, and CP[5]AK has a good therapeutic effect on the damage caused by NM. This study provides a new mechanism and strategy for the treatment of NM exposure-induced skin injuries.
Topics & Concepts
Supramolecular chemistryDetoxification (alternative medicine)Encapsulation (networking)Nitrogen mustardNitrogenMaterials scienceOrganic chemistryChemistryMoleculeBiologyComputer scienceMedicineChemotherapyPathologyComputer networkCyclophosphamideAlternative medicineGeneticsSupramolecular Chemistry and ComplexesMolecular Sensors and Ion DetectionPorphyrin and Phthalocyanine Chemistry