Mechanism of Schwann cells in diabetic peripheral neuropathy: A review
Jingjing Li, Ruiqian Guan, Limin Pan
Abstract
Diabetic peripheral neuropathy (DPN) is the most common neuropathy in the world, mainly manifested as bilateral symmetry numbness, pain or paresthesia, with a high rate of disability and mortality. Schwann cells (SCs), derived from neural ridge cells, are the largest number of glial cells in the peripheral nervous system, and play an important role in DPN. Studies have found that SCs are closely related to the pathogenesis of DPN, such as oxidative stress, endoplasmic reticulum stress, inflammation, impaired neurotrophic support and dyslipidemia. This article reviews the mechanism of SCs in DPN.
Topics & Concepts
MedicinePeripheral neuropathyPathogenesisEndoplasmic reticulumMechanism (biology)Peripheral nervous systemPeripheralInflammationDyslipidemiaNeurotrophic factorsSchwann cellNeurotrophinInternal medicineDiabetes mellitusPathologyEndocrinologyCentral nervous systemCell biologyReceptorEpistemologyBiologyPhilosophyNerve injury and regenerationPain Mechanisms and TreatmentsBotulinum Toxin and Related Neurological Disorders