PD-1 and TIGIT downregulation distinctly affect the effector and early memory phenotypes of CD19-targeting CAR T cells
Young-Ho Lee, Young-Ho Lee, Hyeong Ji Lee, Hyung Cheol Kim, Yujean Lee, Yujean Lee, Su Kyung Nam, Cedric Hupperetz, S. Y. Jennifer, Xinxin Wang, Oded Singer, Won Seog Kim, Seok Jin Kim, Youngil Koh, Inkyung Jung, Chan Hyuk Kim
Topics & Concepts
TIGITDownregulation and upregulationEffectorPhenotypeCD19Cell biologyBiologyImmunologyGeneticsCytotoxic T cellAntibodyGeneIn vitroCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology