Ursonic acid from Artemisia montana exerts anti-diabetic effects through anti-glycating properties, and by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant C2C12 cells
Md Yousof Ali, Se Eun Park, Su Hui Seong, Gerald W. Zamponi, Hyun Ah Jung, Jae Sue Choi
Topics & Concepts
ChemistryIC50Protein kinase BUrsolic acidDocking (animal)Glucose uptakePI3K/AKT/mTOR pathwayBiochemistryInsulinChinese hamster ovary cellPharmacologySignal transductionBiologyReceptorIn vitroEndocrinologyMedicineNursingChromatographyPhytochemicals and Antioxidant ActivitiesNatural Antidiabetic Agents StudiesNatural product bioactivities and synthesis