Prognostic value of the endothelial activation and stress index in patients with upper tract urothelial cancer undergoing radical nephroureterectomy
Jin Seok Gu, Ji Won Ryu, Seong Hyeon Yu, Ho Seok Chung, Jun‐Eul Hwang, Woo Kyun Bae, Ja Yoon Ku, Chan Ho Lee, Hong Koo Ha, Seung Il Jung, Eu Chang Hwang, Dong Deuk Kwon
Abstract
PURPOSE: The relationship with endothelial activation and stress index (EASIX), which represents the degree of endothelial dysfunction, is unwell known in upper tract urothelial carcinoma (UTUC). The present study aims to assess the prognostic value of the EASIX for recurrence-free survival (RFS) and overall survival (OS) in patients with UTUC who underwent radical nephroureterectomy (RNU). MATERIALS AND METHODS: -transformed values. We divided the patients according to the EASIX score (>1.27 vs. ≤1.27). RESULTS: scale. The baseline characteristics were similar between the two groups except for age. The high EASIX score group had worse RFS and OS than the low EASIX score group (log-rank p=0.001 and p=0.006, respectively). At 5 years, the mean RFS and OS difference between the low and high EASIX score groups was 11.1 and 7.35 months, respectively. High EASIX score remained a key prognosticator of RFS and OS after RNU in multivariable analysis. CONCLUSIONS: EASIX score may represent endothelial dysfunction in patients with UTUC and may serve as a readily available prognostic factor for oncologic outcomes.