Highly efficient mRNA delivery with nonlinear microfluidic cell stretching for cellular engineering
Chan Kwon, Aram J. Chung
Abstract
cells per min), cell-type-/cargo-size-insensitive delivery, simple operation (single-step), low analyte consumption, low-cost operation (<$1), and nearly clogging-free operation were demonstrated, demonstrating the high potential of the proposed platform for application in mRNA-based cellular engineering research.
Topics & Concepts
MicrofluidicsIntracellularCellNonlinear systemMessenger RNAViscoelasticityNanotechnologyChemistryBiophysicsMaterials scienceCell biologyBiomedical engineeringBiologyEngineeringPhysicsBiochemistryComposite materialQuantum mechanicsGeneCAR-T cell therapy researchMicrofluidic and Bio-sensing TechnologiesRNA Interference and Gene Delivery