Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature
Hanbi Kim, Hyun Tae Kim, Ji Hye Lee, Hyonseok Hwang, Duk Keun An
Abstract
An efficient protocol for the hydroboration of imines is reported. Lithium halide salts are effective catalysts to convert aldimines and ketimines to their corresponding amines. Here, we report excellent isolated yield of secondary amines (>95%) using 3 mol% lithium bromide in THF at room temperature. In addition, DFT calculations for a plausible reaction pathway are reported.
Topics & Concepts
HydroborationLithium bromideImineChemistryBromideLithium (medication)CatalysisOrganic chemistryMedicinePhysicsEndocrinologyThermodynamicsHeat exchangerOrganoboron and organosilicon chemistryChemical Synthesis and ReactionsChemical Synthesis and Analysis