Highly sensitive and selective surface plasmon resonance biosensor for the detection of SARS-CoV-2 spike S1 protein
Qiong Wu, Wu Wen, Fangfang Chen, Ping Ren
Abstract
(S/N = 3). In the analysis of artificial saliva and human serum samples, the proposed SPR biosensor exhibits good reproducibility and high specificity, which indicates its potential for application in complex bodily fluids. The exploitation of the MXene-based SPR biochip for recognizing the SARS-CoV-2 antigen provides an accessible and rapid way for COVID-19 diagnosis, and promotes the application of 2D nanomaterial-based sensing chips in clinical diagnosis and disease screening. Significantly, the proposed method possesses general applicability that can be reprogrammed to detect any protein antigen if a corresponding specific nanobody is available.
Topics & Concepts
Surface plasmon resonanceBiosensorBiochipNanotechnologyCoronavirusDetection limitAntigenAnalyteSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Materials scienceCoronavirus disease 2019 (COVID-19)ChemistryNanoparticleBiologyChromatographyMedicineInfectious disease (medical specialty)DiseaseImmunologyPathologyAdvanced biosensing and bioanalysis techniquesSARS-CoV-2 detection and testingSARS-CoV-2 and COVID-19 Research