Structure-based Development of Human Interleukin-1β-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP
Wen‐Chih Kuo, Chien‐Chung Lee, Ya-Wen Chang, Wei Wei Pang, Hong‐Sen Chen, Shin‐Chen Hou, Shin‐Yi Lo, An‐Suei Yang, Andrew H.‐J. Wang
Topics & Concepts
AntibodyCytokineNeutralizing antibodyBinding sitePhage displayChemistryMolecular biologyReceptorCell biologyIn vivoBiologyImmunologyBiochemistryGeneticsImmune Cell Function and InteractionToxin Mechanisms and ImmunotoxinsInflammasome and immune disorders