Interrogating bioinspired ESIPT/PCET-based Ir( <scp>iii</scp> )-complexes as organelle-targeted phototherapeutics: a redox-catalysis under hypoxia to evoke synergistic ferroptosis/apoptosis
Maniklal Shee, Dan Zhang, Moumita Banerjee, Samrat Roy, Bipul Pal, Anakuthil Anoop, Youyong Yuan, N. D. Pradeep Singh
Abstract
We investigated organelle-targeted bioinspired ESIPT/PCET-based Ir(iii)-complexes as promising (photo)chemotherapeutic lead compounds which actively operational in redox-catalysis under hypoxia to evoke synergistic ferroptosis/apoptosis.
Topics & Concepts
ChemistryRedoxCatalysisOrganelleHypoxia (environmental)ApoptosisCell biologyBiophysicsOxygenBiochemistryBiologyInorganic chemistryOrganic chemistryNanoplatforms for cancer theranosticsNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in Catalysis