Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis
Zhan Wang, Qingxia Zhao, Yan Nie, Yi Yu, Biswapriya B. Misra, Manal Zabalawi, Jeff W. Chou, Chia-Chi C. Key, Anthony Molina, Matthew Quinn, Michael B. Fessler, John S. Parks, Charles E. McCall, Xuewei Zhu
Abstract
) biosynthesis. Blockade of glycolysis normalizes the differential expression of pro-inflammatory cytokines between control and SLC37A2 deficient macrophages. Conversely, overexpression of SLC37A2 lowers macrophage glycolysis and significantly reduces LPS-induced pro-inflammatory cytokine expression. In conclusion, our study suggests that SLC37A2 dampens murine macrophage inflammation by down-regulating glycolytic reprogramming as a part of macrophage negative feedback system to curtail acute innate activation.
Topics & Concepts
MacrophageGlycolysisInflammationCell biologyLipopolysaccharideMacrophage-activating factorChemistryCytokineNicotinamide adenine dinucleotide phosphateBiologyBiochemistryImmunologyMetabolismEnzymeOxidase testIn vitroImmune cells in cancerAdvanced Glycation End Products researchPhagocytosis and Immune Regulation