What causes malaria anemia?
Nicholas J. White
Abstract
developmental risk window defined in this work.What underlies the acquisition of resilience in this model?The authors speculate that platelets could limit bleeding associated with developmental vascular remodeling, as occurs during formation of mouse mesentery. 7 In that system, activated platelets maintain vascular integrity by extending filopodia at sites of gaps between endothelial cells.Do cell intrinsic changes in thrombopoiesis contribute to the development of resilience?This is the identical timeline for when murine hematopoietic stem cells undergo transcriptional reprogramming from fetal-like to adult-like. 8 How relevant are findings in this mouse model to FNAIT in humans?Although rodents are widely used as experimental models of neonatal brain injury, species differences in the timing of brain maturation can make comparisons of injury susceptibility difficult to interpret. 9The experimental system of Farley et al is based on anti-GP1Ba, yet most cases of human FNAIT are caused by antibodies directed against GPIIb/IIIa. 2,3Moreover, anti-GP1Ba causes both platelet clearance and perturbed GP1Ba signaling, which may enhance the severity of ICH in this model. 5 These caveats notwithstanding, this mouse model may prompt clinicians to thoughtfully consider transfusion practices in neonates with FNAIT given the potential adverse clinical outcomes associated with unneeded platelet transfusions. 10