Design, synthesis, and aldose reductase inhibitory effect of some novel carboxylic acid derivatives bearing 2-substituted-6-aryloxo-pyridazinone moiety
Mevlüt Akdağ, Azime Berna Özçelik, Yeliz Demir, Şükrü Beydemir
Topics & Concepts
ChemistryAldose reductasePolyol pathwaySorbitolCarboxylic acidAldehyde ReductaseStereochemistryMoietyEnzymeSorbitol dehydrogenaseFructoseBiochemistryAldose Reductase and TaurineEnzyme function and inhibitionChemical synthesis and pharmacological studies