Outbreak of IncX8 Plasmid–Mediated KPC-3–Producing Enterobacterales Infection, China
Lan Chen, Wenxiu Ai, Ying Zhou, Chunyang Wu, Yinjuan Guo, Xiaocui Wu, Bingjie Wang, Lulin Rao, Yanlei Xu, Jiao Zhang, Liang Chen, Fangyou Yu
Abstract
C arbapenemase-producing Enterobacterales (CPE) have emerged as important nosocomial pathogens and are a global public health concern because of the high prevalence of CRE infection and its associated mortality rate. Currently, Klebsiella pneumoniae carbapenemase (KPC) is the most clinically important carbapenemase globally (1,2). Since its first discovery in 1996 (3), more than 90 KPC variants have been documented, of which KPC-2 and KPC-3 are the most common clinical variants (4). bla KPC genes are frequently harbored by Tn4401 or non-Tn4401 mobile elements (NTM KPC ) (5), and the spread of bla KPC has been primarily associated with transmissible plasmids, belonging to different incompatibility groups (e.g., IncFII, IncI2, IncX, IncA/C, IncR, IncN, and ColE) (5).