Cathelicidins Target HSP60 To Restrict CVB3 Transmission via Disrupting the Exosome and Reducing Cardiomyocyte Apoptosis
Yang Yang, Chunjing Huang, Hui Li, Yahui Song, Yuxuan Fu, Min Li, Hailong Yang, Jing Wu, Jia Sun, Wei Xu, Lin Wei
Abstract
The relative mechanisms that cathelicidin antimicrobial peptides use to influence nonenveloped virus infection are unclear. We show here that cathelicidin antimicrobial peptides (CRAMP and LL-37) directly target exosomal HSP60 to destroy exosomes, which in turn block the diffusion of exosomes to recipient cardiomyocytes and reduced HSP60-induced apoptosis, thus restricting coxsackievirus B3 infection. Our results provide new insights into the mechanisms cathelicidin antimicrobial peptides use against viral infection.
Topics & Concepts
CathelicidinBiologyMicrovesiclesExosomeAntimicrobial peptidesCoxsackievirusApoptosisAntimicrobialVirologyCell biologyMicrobiologyImmunologyVirusmicroRNAEnterovirusGeneticsGeneAntimicrobial Peptides and ActivitiesVector-borne infectious diseasesViral Infections and Immunology Research