Insights into auto- <i>S</i> -fatty acylation: targets, druggability, and inhibitors
Lu Hu, Zhipeng Tao, Xu Wu
Abstract
Posttranslational S -fatty acylation (or S -palmitoylation) modulates protein localization and functions, and has been implicated in neurological, metabolic, and infectious diseases, and cancers.
Topics & Concepts
DruggabilityPalmitoylationAcylationChemistryBiochemistryBiologyCell biologyEnzymeGeneCatalysisCysteineFibroblast Growth Factor ResearchLipid metabolism and biosynthesisEndoplasmic Reticulum Stress and Disease