Cell type–specific microRNA therapies for myocardial infarction
Bohao Liu, Bryan Wang, Xiaokan Zhang, Roberta I. Lock, Trevor R. Nash, Gordana Vunjak‐Novakovic
Abstract
Current interventions fail to recover injured myocardium after infarction and prompt the need for development of cardioprotective strategies. Of increasing interest is the therapeutic use of microRNAs to control gene expression through specific targeting of mRNAs. In this Review, we discuss current microRNA-based therapeutic strategies, describing the outcomes and limitations of key microRNAs with a focus on target cell types and molecular pathways. Last, we offer a perspective on the outlook of microRNA therapies for myocardial infarction, highlighting the outstanding challenges and emerging strategies.
Topics & Concepts
Myocardial infarctionmicroRNAMedicineCellCardiologyBioinformaticsBiologyBiochemistryGeneMicroRNA in disease regulationCircular RNAs in diseasesExtracellular vesicles in disease