Electro-mechanical coupling directs endothelial activities through intracellular calcium ion deployment
Changhao Li, Peng Yu, Zhengao Wang, Cheng Long, Cairong Xiao, Jun Xing, Binbin Dong, Jinxia Zhai, Lei Zhou, Zhengnan Zhou, Yan Wang, Wenjun Zhu, Guoxin Tan, Chengyun Ning, Yahong Zhou, Chuanbin Mao
Abstract
. Such an electro-mechanical coupling feedback loop directs pre-angiogenic activities such as alignment, elongation, and migration of HUVECs. Activated calcium dynamics during the coupling further modulate the downstream angiogenesis-inducing eNOS/NO pathway. These findings lay a foundation for developing new ways of electrical stimulation-based disease treatment.
Topics & Concepts
Umbilical veinCoupling (piping)Mechanosensitive channelsBiophysicsCalciumAngiogenesisIntracellularMechanotransductionExtracellularChemistryCell biologyIon channelMaterials scienceBiologyBiochemistryMetallurgyReceptorIn vitroOrganic chemistryCancer researchPlanarian Biology and ElectrostimulationCellular Mechanics and InteractionsErythrocyte Function and Pathophysiology