Characterization of the Novel P2X7 Receptor Radioligand [<sup>3</sup>H]JNJ-64413739 in Human Brain Tissue
Jens D. Mikkelsen, Sanjay S. Aripaka, Sif Kaad, Burcu Azak Pazarlar, Lars H. Pinborg, Bente Finsen, Andrea Varrone, Benny Bang‐Andersen, Jesper F. Bastlund
Abstract
H]JNJ-64413739 is a suitable radioligand for evaluating the distribution and expression of the P2X7R in the human brain.
Topics & Concepts
RadioligandWhite matterHuman brainNeuroinflammationReceptorLigand (biochemistry)Internal medicineMicrogliaPurinergic receptorEndocrinologyChemistryBiologyNeurosciencePathologyMedicineInflammationMagnetic resonance imagingRadiologyAdenosine and Purinergic SignalingNeurological Complications and SyndromesNeuroscience of respiration and sleep