Targeting dual gene delivery nanoparticles overcomes immune checkpoint blockade induced adaptive resistance and regulates tumor microenvironment for improved tumor immunotherapy
Yuanji Feng, Jiayan Wu, Jie Chen, Lin Lın, Sijia Zhang, Zhiyu Yang, Pingjie Sun, Yanhui Li, Huayu Tian, Xuesi Chen
Topics & Concepts
ImmunotherapyBlockadeImmune checkpointTumor microenvironmentCancer researchImmune systemGene silencingMelanomaGenetic enhancementMedicineImmunologyBiologyGeneInternal medicineReceptorBiochemistryImmunotherapy and Immune ResponsesCAR-T cell therapy researchCancer Immunotherapy and Biomarkers