Amidation of methyl ester-functionalised poly(2-oxazoline)s as a powerful tool to create dual pH- and temperature-responsive polymers as potential drug delivery systems
Meike N. Leiske, Ronak Singha, Somdeb Jana, Bruno G. De Geest, Richard Hoogenboom
Abstract
We present the synthesis of different amine-functionalised poly(2-oxazoline)s, their dual pH and temperature response as well as their capability to as promising stimuli responsive drug delivery vectors.
Topics & Concepts
OxazolineDrug deliveryAmine gas treatingPolymerCombinatorial chemistryChemistryDual (grammatical number)DrugOrganic chemistryPharmacologyCatalysisMedicineArtLiteratureSynthesis and properties of polymersAdvanced Polymer Synthesis and CharacterizationDendrimers and Hyperbranched Polymers