Diols Activation by Cu/Borinic Acids Synergistic Catalysis in Atroposelective Ring‐Opening of Cyclic Diaryliodoniums
Kun Zhao, Shan Yang, Qi Gong, Longhui Duan, Zhenhua Gu
Abstract
A Cu-catalyzed enantioselective ring-opening alkoxygenation reaction of cyclic diaryliodonium salts and diols in the presence of borinic acids was reported. Tuning structure of borinic acids with six or five-membered ring skeleton could selectively activate 1,2-diols or 1,4-diols. A catalytic cycle through a key ion pair model that accounts for the observed enantioselectivity was proposed.
Topics & Concepts
ChemistryRing (chemistry)Enantioselective synthesisCatalysisOrganic chemistryMedicinal chemistryPolymer chemistryAxial and Atropisomeric Chirality SynthesisAlkaloids: synthesis and pharmacologyPlant and Fungal Species Descriptions