Blunted peripheral but not cerebral vasodilator function in young otherwise healthy adults with persistent symptoms following COVID-19
Damsara Nandadeva, Benjamin E. Young, Brandi Y. Stephens, Ann‐Katrin Grotle, Rachel J. Skow, Angela J. Middleton, Florence P. Haseltine, Paul J. Fadel
Abstract
This study was the first to investigate the persistent effects of COVID-19 on vascular function in otherwise healthy young adults. We demonstrated that peripheral macrovascular and microvascular vasodilation was significantly blunted in young adults still symptomatic from COVID-19 beyond the acute phase (>4 wk from diagnosis), whereas those who become asymptomatic have similar vascular function compared with controls who never had COVID-19. In contrast, cerebral vascular function and central arterial stiffness were unaffected irrespective of COVID-19 symptomology.
Topics & Concepts
AsymptomaticMedicineReactive hyperemiaPeripheralBrachial arteryArterial stiffnessVasodilationCardiologyInternal medicineCuffHypercapniaCoronavirus disease 2019 (COVID-19)Cerebral blood flowAnesthesiaRespiratory systemBlood pressureSurgeryDiseaseInfectious disease (medical specialty)Long-Term Effects of COVID-19Heart Rate Variability and Autonomic ControlCOVID-19 Clinical Research Studies