Single-arm clinical trials that supported FDA accelerated approvals have modest effect sizes and were at high risk of bias
Tatiane Bomfim Ribeiro, Luis Enrique Colunga‐Lozano, Ana Paula Vieira Araujo, Charles L. Bennett, Iztok Hozo, Benjamin Djulbegović
Topics & Concepts
MedicineClinical trialPublication biasResearch designMeta-analysisRandomized controlled trialInternal medicineStatisticsMathematicsStatistical Methods in Clinical TrialsAdvanced Causal Inference TechniquesHealth Systems, Economic Evaluations, Quality of Life