Immunostimulatory effects of radioimmunotherapy
Julie Constanzo, Lorenzo Galluzzi, Jean‐Pierre Pouget
Abstract
Radiation therapy (RT) is known for its ability to kill cancer cells in an immunogenic manner. Recent preclinical data demonstrate that targeted alpha-particle therapy shares with RT the capacity to elicit immunostimulatory effects, standing out as a promising strategy to circumvent immune checkpoint inhibitor resistance in immunologically 'cold' tumors.
Topics & Concepts
RadioimmunotherapyMedicineCancer researchImmune systemRadiation therapyImmunotherapyImmunologyOncologyInternal medicineAntibodyMonoclonal antibodyImmunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersLung Cancer Research Studies