Synthesis and biological evaluation of geniposide derivatives as potent and selective PTPlB inhibitors
Shuwen Lei, Dongdong Zhang, Yunyue Qi, Sharmin Reza Chowdhury, Ran Sun, Juntao Wang, Yi Du, Lei Fu, Faqin Jiang
Topics & Concepts
ChemistrySelectivityCytotoxicityBiological activityProtein tyrosine phosphataseIn vitroDocking (animal)Structure–activity relationshipEnzymeChemical synthesisBiochemistryEnzyme inhibitorIC50Molecular modelStereochemistryGlycosylMedicineNursingCatalysisProtein Tyrosine PhosphatasesSphingolipid Metabolism and SignalingSaffron Plant Research Studies