Strategies for Inhibition and Disaggregation of Amyloid‐β Fibrillation
Hao Geng, Dong Gao, Zijuan Wang, Xiaoning Liu, Zhanshuo Cao, Chengfen Xing
Abstract
Comprehensive Summary Amyloid‐β protein (Aβ) is a fatal cause of Alzheimer's disease, which can trigger a series of cytotoxicity by the abnormal aggregation of Aβ in human brain. The strategies for inhibition and disaggregation of Aβ fibrillation are mostly based on the interaction between monomers, oligomers, fibrils, and materials. This review summarizes recent researches of materials and regulation of interactions for inhibiting Aβ aggregation and disaggregating Aβ fibrils. The materials have been reviewed and divided into several kinds according to molecular type. And the regulation of interactions between materials and Aβ protein mainly focuses on covalent interaction, non‐covalent interaction and photoactivated effect based on covalent and non‐covalent interaction. In this review, the photodynamic effect and photothermal effect on regulation of Aβ aggregation are summarized in detail. In the end, the challenges and outlook of the application prospects on the strategies for inhibition and disaggregation of Aβ fibrillation are estimated.