Litcius/Paper detail

Down Syndrome in a New Era for Alzheimer Disease

Michael S. Rafii, Juan Fortea

2023JAMA42 citationsDOIOpen Access PDF

Abstract

This Viewpoint explains the genetic association between Alzheimer disease and Down syndrome and the negative impact of excluding people with Down syndrome from clinical trials on treatment for Alzheimer disease.

Topics & Concepts

MedicineDiseaseAlzheimer's diseaseDown syndromeClinical trialPsychiatryInternal medicineDown syndrome and intellectual disability researchChronic Disease Management StrategiesDementia and Cognitive Impairment Research