Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo
Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D. P. Cosford, Jerome A. Zack, Sumit K. Chanda
Abstract
efficacy and safety of Ciapavir and indicates that Smac mimetics can constitute a critical component of a safe and efficacious treatment strategy to eliminate the latent HIV-1 reservoir.
Topics & Concepts
In vivoVirus latencyHuman immunodeficiency virus (HIV)Ex vivoNF-κBLatency (audio)Signal transductionBiologyChemistryImmunologyMedicineVirusCell biologyViral replicationComputer scienceBiotechnologyTelecommunicationsHIV Research and TreatmentHIV/AIDS drug development and treatmentImmune Cell Function and Interaction