Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis
Ting Pan, Qing Zhou, Kang Miao, Lei Zhang, Guorao Wu, Jun Yu, Yongjian Xu, Weining Xiong, Yong Li, Yi Wang
Abstract
Our study provides a valuable reference for modulating macrophage polarization and a promising strategy for the treatment of pulmonary fibrosis in clinical settings.
Topics & Concepts
BleomycinIdiopathic pulmonary fibrosisPulmonary fibrosisMacrophage polarizationMedicineLiposomeLungFibrosisMacrophageIn vivoCancer researchCationic liposomeAlveolar macrophagePathogenesisPathologyImmunologyIn vitroTransfectionChemistryBiologyInternal medicineChemotherapyCell cultureBiochemistryBiotechnologyGeneticsInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisMedical Imaging and Pathology StudiesExtracellular vesicles in disease