HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models
Estanislao Peixoto, Sujeong Jin, Kristen M. Thelen, Aalekhya Biswas, Seth Richard, Manuela Morleo, Adrián P. Mansini, Stephanie Holtorf, Fabrizia Carbone, Nunzia Pastore, Andrea Ballabio, Brunella Franco, Sergio A. Gradilone
2020American Journal of Physiology-Gastrointestinal and Liver Physiology37 citationsDOIOpen Access PDF
Abstract
This work identifies novel targets against primary ciliary disassembly that can lead to new cholangiocarcinoma therapeutic strategies. Furthermore, ciliary loss has been described in different tumors, increasing the significance of our research.
Topics & Concepts
CiliumHDAC6Cancer researchBiologyCell biologyGeneticsHistoneHistone deacetylaseGeneEpigenetics and DNA MethylationPeptidase Inhibition and AnalysisMicroRNA in disease regulation