Biodegradable Zwitterionic Cream Gel for Effective Prevention of Postoperative Adhesion
Ershuai Zhang, Jianhai Yang, Ke Wang, Boyi Song, Hui Zhu, Xiangfei Han, Yuanjie Shi, Chengbiao Yang, Zhipeng Zeng, Zhiqiang Cao
Abstract
Postoperative peritoneal adhesions were frequent complications for almost any types of abdominal and pelvic surgery. This led to numerous medical problems and huge financial burden to the patients. Current anti-adhesion strategies focused mostly on physical barriers including films and hydrogels. However, they can only alleviate or reduce adhesions to certain level and their applying processes were far from ideal. This work reported the development of a biodegradable zwitterionic cream gel presenting a series of characters for an idea anti-adhesion material, including unique injectable yet malleable and self-supporting properties, which enabled an instant topical application, no curing, waiting or suturing, no hemostasis requirement, protein/cell resistance and biodegradability. The cream gel showed a major advancement in anti-adhesion efficacy by completely and reliably preventing a primary and a more severe recurrent adhesion in rat models.