Deciphering the origin of the melting profile of unilamellar phosphatidylcholine liposomes by measuring the turbidity of its suspensions
Petra Maleš, Barbara Pem, Dražen Petrov, Darija Domazet Jurašin, Danijela Bakarić
Abstract
), and based on the changes in turbidities, the thickness of the lipid bilayer in LUV was determined. The obtained data suggested that the curvature change is a key distinguishing factor in MLV and LUV heat capacity profiles. By combining the experimental results and those obtained by MD simulations, the interfacial water layer was characterized and its contribution to the thermal properties of LUV was discussed.
Topics & Concepts
LiposomeDifferential scanning calorimetryBilayerChemistryPhosphatidylcholineLipid bilayerVesicleHeat capacityAnalytical Chemistry (journal)Thermal analysisChromatographyChemical engineeringThermodynamicsPhospholipidMembraneThermalBiochemistryEngineeringPhysicsLipid Membrane Structure and BehaviorSurfactants and Colloidal SystemsProteins in Food Systems