A mixed-valence biotinylated Cu(<scp>i</scp>/<scp>ii</scp>) complex for tumor-targeted chemodynamic therapy accompanied by GSH depletion
Zhao-Guo Hong, Xin You, Jingjing Zhong, Di Yao, He‐Dong Bian, Shulin Zhao, Liangliang Zhang, Hong Liang, Fu‐Ping Huang
Abstract
A “three in one” project involved atomically precise biotinylated complex, VBio-CuICuII, composed of a hydroxyl radical-producible Cu( i ), a Cu( ii ) moiety as a GSH depletor for augmented CDT, and biotin as a cancer-targeting unit.
Topics & Concepts
BiotinylationMoietyChemistryValence (chemistry)Residue (chemistry)Combinatorial chemistryBiochemistryStereochemistryOrganic chemistryMagnetism in coordination complexesLanthanide and Transition Metal ComplexesClick Chemistry and Applications