Intracellular calcium dynamics of lymphatic endothelial and muscle cells co-cultured in a Lymphangion-Chip under pulsatile flow
Amirali Selahi, Sanjukta Chakraborty, Mariappan Muthuchamy, David C. Zawieja, Abhishek Jain
Abstract
A Lymphangion-Chip consisting an endothelial lumen co-cultured with muscle cells was exposed to step or pulsatile flow. The real-time analyses of intracellular calcium dynamics reveal the coupling of signaling between these cells under complex flows.
Topics & Concepts
Pulsatile flowCalciumLymphatic EndotheliumCalcium in biologyIntracellularBiophysicsCell biologyContractilityLymphatic systemMechanotransductionChemistryAnatomyBiologyEndocrinologyImmunologyOrganic chemistryLymphatic System and DiseasesPlanarian Biology and ElectrostimulationSpaceflight effects on biology