Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling
Guangwen Shu, Hui Sun, Tiantian Zhang, Anqi Zhu, Lei Xiao, Chuo Wang, Anning Song, Xukun Deng
Topics & Concepts
AMPKProtein kinase APhosphorylationCell biologyGene knockdownChemistryHepatic stellate cellAMP-activated protein kinaseSignal transductionKinaseGSK-3GSK3BMolecular biologyBiologyBiochemistryEndocrinologyApoptosisLiver Disease Diagnosis and TreatmentGenomics, phytochemicals, and oxidative stressMetabolism, Diabetes, and Cancer