Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson’s Dementia in Humans
Amanda K. E. Hornsby, Luke Buntwal, Maria Carla Carisi, Vanessa Valgas dos Santos, Fionnuala Johnston, Luke D. Roberts, Martina Sassi, Mathieu Méquinion, Romana Stark, Alex Reichenbach, Sarah H. Lockie, Mario Siervo, Owain W. Howell, Alwena H. Morgan, Timothy Wells, Zane B. Andrews, David J. Burn, Jeffrey S. Davies
Abstract
cell number was reduced in PDD. We identify UAG as a regulator of hippocampal-dependent plasticity and spatial memory and AG:UAG as a putative circulating diagnostic biomarker of dementia.
Topics & Concepts
NeurogenesisHippocampal formationNeuroscienceGhrelinHippocampusDementiaParkinson's diseasePsychologyMedicineInternal medicineHormoneDiseaseRegulation of Appetite and ObesityAdipose Tissue and MetabolismNeurogenesis and neuroplasticity mechanisms