Zero- to Ultralow-Field NMR Spectroscopy of Small Biomolecules
Piotr Put, Szymon Pustelny, Dmitry Budker, Emanuel Druga, Tobias F. Sjolander, Alexander Pines, Danila A. Barskiy
Abstract
C]-d-glucose were acquired, and an approach relying on the presence of a transverse magnetic field during the detection was investigated for relaxometry purposes. We found that the water relaxation time strongly depends on the concentration of dissolved d-glucose in the range of 1-10 mM suggesting opportunities for indirect assessment of glucose concentration in aqueous solutions. Extending analytical capabilities of zero-field NMR to aqueous solutions of simple biomolecules (amino acids, sugars, and metabolites) and relaxation studies of aqueous solutions of glucose highlights the analytical potential of noninvasive and portable ZULF NMR sensors for applications outside of research laboratories.