Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation
Scott Rosenberg, Frances Shanahan, Sayumi Yamazoe, Marc Kschonsak, Yi Jimmy Zeng, James Lee, Emile G. Plise, Ivana Yen, Christopher M. Rose, John G. Quinn, Lewis Gazzard, Benjamin T. Walters, Donald S. Kirkpatrick, Steven T. Staben, Scott A. Foster, Shiva Malek
Topics & Concepts
MutantEpidermal growth factor receptorProtein degradationChemistryKineticsCell biologyBiophysicsHydrogen–deuterium exchangeTernary complexDegradation (telecommunications)BiochemistryBiologyReceptorMass spectrometryEnzymeChromatographyGenePhysicsComputer scienceQuantum mechanicsTelecommunicationsProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysCAR-T cell therapy research