Emerging investigator series: human CYP2A6 catalyzes the oxidation of 6:2 fluorotelomer alcohol
Oluwadamilola Daramola, Amy A. Rand
Abstract
value. Collectively, these findings provide a mechanistic perspective on the potential importance of CYP2A6 in the metabolic activation and phase I elimination of 6:2 FTOH and indirect human exposure to PFCAs.
Topics & Concepts
CYP2A6ChemistryMicrosomeBiotransformationCytochrome P450EnzymeMetabolismBiochemistryCYP3A4Per- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals