Mn(III)-Mediated Radical Addition/Cyclization of Isocyanides with Aryl Boronic Acids/Diarylphosphine Oxides: Access to 11-Functionalized Dibenzodiazepines
Xuan Liu, Sitian Yuan, Yi Liu, Mengjia Ni, Jianbo Xu, Shuanggen Gui, Yiyuan Peng, Qiuping Ding
Abstract
A Mn(III)-mediated radical addition/cyclization reaction of isocyanides with aryl boronic acids/diarylphosphine oxides has been developed. A series of 11-arylated/-phosphorylated dibenzodiazepines were efficiently constructed in moderate to excellent yields under mild reaction conditions via imidoyl radical process. The present protocol offers novel access to functionalized seven-membered N-heterocycles.
Topics & Concepts
ArylChemistryIsocyanideCombinatorial chemistryRadical cyclizationMedicinal chemistryOrganic chemistryAlkylRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques