Carbon monoxide as the key: carbonylation triggered (hetero)aryl migration transformations
Hefei Yang, Xiao‐Feng Wu
Abstract
, diazo-derived, oxygen-centered, trifluoromethylthio, alkoxycarbonyl, phosphinyl, nitrogen-centered, cobalt-hydride, and hydrogen-bonding-assisted species-that promote intermolecular and intramolecular functional group migrations under mild conditions. Key to these transformations is the synergistic interplay between CO insertion and migration events, which collectively enable remote aryl or heteroaryl transfer to carbonyl carbons, yielding valuable 1,4-dicarbonyl compounds, lactones, and other functionalized scaffolds. The review also highlights mechanistic insights, substrate adaptability, and the ability to overcome traditional limitations in selectivity and reactivity. Despite significant progress, challenges remain in expanding migration scope, simplifying substrate design, and achieving asymmetric catalysis. This work aims to inspire further innovation in CO-mediated synthetic methodologies.