The m <sup>6</sup> A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis
Rami Bechara, Nilesh Amatya, Rachel D. Bailey, Yang Li, Felix E.Y. Aggor, Dedong Li, Chetan V. Jawale, Bianca M. Coleman, Ning Dai, Nandan S. Gokhale, Tiffany C. Taylor, Stacy M. Horner, Amanda C. Poholek, Anita Bansal, Partha S. Biswas, Sarah L. Gaffen
Abstract
The m6A “reader” IMP2 promotes cytokine-induced kidney autoimmunity by posttranscriptional control of C/EBPβ/δ transcription factors.
Topics & Concepts
Transcription factorAutoimmunityInflammationCytokineTranscription (linguistics)Tumor necrosis factor alphaImmunologyBiologyMolecular biologyCell biologyGeneticsGeneAntibodyLinguisticsPhilosophyRNA modifications and cancerCancer-related gene regulationRNA Research and Splicing